Human hepatic blood flow and its relation to systemic circulation during intravenous infusion of lidocaine.
نویسنده
چکیده
Twelve healthy young volunteers were studied before and during intravenous administration of lidocaine at a dose rate of 2 or 4 mg/min. Five additional volunteers, who did not receive lidocaine solution but were given the same amount of physiological saline, were studied in the same manner. Heart rate, cardiac output, mean arterial blood pressure, mean right atrial blood pressure, estimated hepatic blood flow and plasma concentration of lidocaine were measured repeatedly. The results showed an increase in heart rate, cardiac output and mean arterial blood pressure, the latter two variables in relation to the plasma concentration of lidocaine. The estimated hepatic blood flow increased, partly as a result of the reduction of splanchnic vascular resistance and partly due to the stimulation of cardiac output. The decrease in splanchnic vascular resistance was proportional to the plasma concentration of lidocaine.
منابع مشابه
Evaluation of Intravenous Lidocaine Overdose in Chickens (Gallus domesticus)
Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) Procedure- A loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose o...
متن کاملInterrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man.
Factors that regulate the arterial level of lidocaine during a constant infusion were investigated in 17 patients undergoing cardiac catheterization. Lidocaine was administered by a 50 mg bolus, followed by a constant infusion of 40 ug/kg/min until steady state conditions were achieved. Cardiac output and estimated hepatic blood flow were also determined. An inverse relationship between arteria...
متن کاملRenal and systemic hemodynamic responses to intravenous infusion of leukotriene C4 in the rat.
We studied the systemic and renal hemodynamic effects of leukotriene C4 (2 micrograms/kg per min for 5 minutes, iv) in the rat. During the period of its infusion, leukotriene C4 produced a significant elevation of mean arterial pressure and reductions in cardiac output and renal blood flow, as measured by electromagnetic flow probes. These effects were abolished by FPL55712 , a putative antagon...
متن کاملEffects of certain i.v. anaesthetics on liver blood flow and hepatic oxygen consumption in the greyhound.
The effects of increasing concentrations of thiopentone, Althesin and etomidate on liver blood flow and hepatic oxygen consumption were investigated in the anaesthetized greyhound. All three agents studied produced dose-related decreases in general cardiovascular indices such as mean arterial pressure, cardiac output and systemic vascular resistance; all three anaesthetics produced decreases in...
متن کاملP-247: To Evaluate The Oxytocin Effect on Maternal-Fetal Circulation during Termination of Pregnancy
Background: To evaluate the effect of oxytocin on blood circulation of fetus and uterus by Doppler ultrasound. Materials and Methods: Forty six pregnant women were assigned to receive for indication of delivery intravenous oxytocin. Doppler velocitometry before and after administration of oxytocin for umbilical,middle cerebral artery and uterine artery were performed, and Pulsatility index (PI)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta anaesthesiologica Scandinavica
دوره 21 2 شماره
صفحات -
تاریخ انتشار 1977